Ontology highlight
ABSTRACT:
SUBMITTER: LaMothe RA
PROVIDER: S-EPMC5840162 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
LaMothe Robert A RA Kolte Pallavi N PN Vo Trinh T Ferrari Joseph D JD Gelsinger Tracy C TC Wong Jodie J Chan Victor T VT Ahmed Sinthia S Srinivasan Aditi A Deitemeyer Patrick P Maldonado Roberto A RA Kishimoto Takashi K TK
Frontiers in immunology 20180302
T cells reacting to self-components can promote tissue damage when escaping tolerogenic control mechanisms which may result in autoimmune disease. The current treatments for these disorders are not antigen (Ag) specific and can compromise host immunity through chronic suppression. We have previously demonstrated that co-administration of encapsulated or free Ag with tolerogenic nanoparticles (tNPs) comprised of biodegradable polymers that encapsulate rapamycin are capable of inhibiting Ag-specif ...[more]