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Febuxostat methanol solvate.

ABSTRACT: In the title compound {systematic name: [2-(3-cyano-4-isobutyl-oxyphen-yl)-4-methyl-1,3-thia-zole-5-carb-oxy-lic acid (febuxostat) methanol monosolvate}, C(16)H(16)N(2)O(3)S·CH(4)O, the benzene and thia-zole rings in the febuxostat mol-ecule are twisted at 5.3?(1)°. In the crystal structure, inter-molecular O-H?O and O-H?N hydrogen bonds link the febuxostat and methanol mol-ecules into helical chains along the 2(1) screw axis.

SUBMITTER: Jiang QY

PROVIDER: S-EPMC3089318 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

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Febuxostat methanol solvate.

Jiang Qi-Ying QY Qian Jing-Jing JJ Gu Jian-Ming JM Tang Gu-Ping GP Hu Xiu-Rong XR

Acta crystallographica. Section E, Structure reports online 20110429 Pt 5

In the title compound {systematic name: [2-(3-cyano-4-isobutyl-oxyphen-yl)-4-methyl-1,3-thia-zole-5-carb-oxy-lic acid (febuxostat) methanol monosolvate}, C(16)H(16)N(2)O(3)S·CH(4)O, the benzene and thia-zole rings in the febuxostat mol-ecule are twisted at 5.3 (1)°. In the crystal structure, inter-molecular O-H⋯O and O-H⋯N hydrogen bonds link the febuxostat and methanol mol-ecules into helical chains along the 2(1) screw axis. ...[more]

PMID: 21754528

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