Ontology highlight
ABSTRACT:
SUBMITTER: Sheng J
PROVIDER: S-EPMC3089452 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Nucleic acids research 20110117 9
We report here the first synthesis of 5-phenyl-telluride-thymidine derivatives and the Te-phosphoramidite. We also report here the synthesis, structure and STM current-imaging studies of DNA oligonucleotides containing the nucleobases (thymine) derivatized with 5-phenyl-telluride functionality (5-Te). Our results show that the 5-Te-DNA is stable, and that the Te-DNA duplex has the thermo-stability similar to the corresponding native duplex. The crystal structure indicates that the 5-Te-DNA duple ...[more]