Ontology highlight
ABSTRACT:
SUBMITTER: Sano H
PROVIDER: S-EPMC3089496 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Sano Hiroyuki H Peck Grantley R GR Kettenbach Arminja N AN Gerber Scott A SA Lienhard Gustav E GE
The Journal of biological chemistry 20110322 19
Insulin-stimulated translocation of the glucose transporter GLUT4 to the cell surface in fat and muscle cells is the basis for insulin-stimulated glucose transport. Studies in adipocytes strongly support the following molecular mechanism for this process. Insulin-elicited phosphorylation of the GTPase-activating protein TBC1D4 (AS160) suppresses its activity toward Rab10 and thereby leads to an increase in the GTP-bound form of Rab10, which in turn triggers movement of vesicles containing GLUT4 ...[more]