Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC2729519 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Chen Yu Y Deng Yongqiang Y Zhang Jinzhong J Yang Lu L Xie Xiangyang X Xu Tao T
The Biochemical journal 20090813 2
Insulin stimulates GLUT4 (glucose transporter 4) translocation in adipocytes and muscles. An emerging picture is that Rab10 could bridge the gap between the insulin signalling cascade and GLUT4 translocation in adipocytes. In the present study, two potential effectors of Rab10, GDI (guanine-nucleotide-dissociation inhibitor)-1 and GDI-2, are characterized in respect to their roles in insulin-stimulated GLUT4 translocation. It is shown that both GDI-1 and GDI-2 exhibit similar distribution to GLU ...[more]