Ontology highlight
ABSTRACT:
SUBMITTER: Kedei N
PROVIDER: S-EPMC3089703 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Kedei Noemi N Telek Andrea A Czap Alexandra A Lubart Emanuel S ES Czifra Gabriella G Yang Dazhi D Chen Jinqiu J Morrison Tyler T Goldsmith Paul K PK Lim Langston L Mannan Poonam P Garfield Susan H SH Kraft Matthew B MB Li Wei W Keck Gary E GE Blumberg Peter M PM
Biochemical pharmacology 20110330 11
Bryostatin 1 has attracted considerable attention both as a cancer chemotherapeutic agent and for its unique activity. Although it functions, like phorbol esters, as a potent protein kinase C (PKC) activator, it paradoxically antagonizes many phorbol ester responses in cells. Because of its complex structure, little is known of its structure-function relations. Merle 23 is a synthetic derivative, differing from bryostatin 1 at only four positions. However, in U-937 human leukemia cells, Merle 23 ...[more]