Ontology highlight
ABSTRACT:
SUBMITTER: Horowitz ED
PROVIDER: S-EPMC3089942 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Horowitz Eric D ED Weinberg Marc S MS Asokan Aravind A
Bioconjugate chemistry 20110309 4
A chemical approach for selective masking of arginine residues on viral capsids featuring an exogenous glycation reaction has been developed. Reaction of adeno-associated viral (AAV) capsids with the α-dicarbonyl compound, methylglyoxal, resulted in formation of arginine adducts. Specifically, surface-exposed guanidinium side chains were modified into charge neutral hydroimidazolones, thereby disrupting a continuous cluster of basic amino acid residues implicated in heparan sulfate binding. Cons ...[more]