Ontology highlight
ABSTRACT:
SUBMITTER: Davidsson M
PROVIDER: S-EPMC6936499 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Davidsson Marcus M Wang Gang G Aldrin-Kirk Patrick P Cardoso Tiago T Nolbrant Sara S Hartnor Morgan M Mudannayake Janitha J Parmar Malin M Björklund Tomas T
Proceedings of the National Academy of Sciences of the United States of America 20191209 52
Adeno-associated virus (AAV) capsid modification enables the generation of recombinant vectors with tailored properties and tropism. Most approaches to date depend on random screening, enrichment, and serendipity. The approach explored here, called BRAVE (barcoded rational AAV vector evolution), enables efficient selection of engineered capsid structures on a large scale using only a single screening round in vivo. The approach stands in contrast to previous methods that require multiple generat ...[more]