Ontology highlight
ABSTRACT:
SUBMITTER: Towers RJ
PROVIDER: S-EPMC309019 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Journal of clinical microbiology 20031201 12
Streptococcal fibronectin-binding protein is an important virulence factor involved in colonization and invasion of epithelial cells and tissues by Streptococcus pyogenes. In order to investigate the mechanisms involved in the evolution of sfbI, the sfbI genes from 54 strains were sequenced. Thirty-four distinct alleles were identified. Three principal mechanisms appear to have been involved in the evolution of sfbI. The amino-terminal aromatic amino acid-rich domain is the most variable region ...[more]