Ontology highlight
ABSTRACT:
SUBMITTER: Curtin K
PROVIDER: S-EPMC3090226 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Curtin Karen K Slattery Martha L ML Samowitz Wade S WS
Pathology research international 20110412
The concept of a CpG island methylator phenotype, or CIMP, quickly became the focus of several colorectal cancer studies describing its clinical and pathological features after its introduction in 1999 by Toyota and colleagues. Further characterization of CIMP in tumors lead to widespread acceptance of the concept, as expressed by Shen and Issa in their 2005 editorial, "CIMP, at last." Since that time, extensive research efforts have brought great insights into the epidemiology and prognosis of ...[more]