Dataset Information

Polymorphisms in the mannose binding lectin-2 gene and acute respiratory distress syndrome.

ABSTRACT:

Objective

The variant alleles in the mannose binding lectin-2 (MBL-2) gene have been associated with MBL deficiency and increased susceptibility to sepsis. We postulate that the variant MBL-2 genotypes are associated with increased susceptibility to and mortality in acute respiratory distress syndrome (ARDS).

Design

Nested case-control study.

Setting

Tertiary academic medical center.

Patients

Two hundred and twelve Caucasians with ARDS and 442 controls genotyped for the variant X, D, B, and C alleles of codon -221, 52, 54, and 57, respectively.

Interventions

None.

Measurements and main results

Patients homozygous for the variant codon 54B allele (54BB) had worse severity of illness on admission (p = .007), greater likelihood of septic shock (p = .04), and increased odds of ARDS (adjusted odds ratio, 6.7; 95% confidence interval, 1.5-31) when compared with heterozygotes and homozygotes for the wild-type allele. This association with ARDS was especially strong among the 311 patients with septic shock (adjusted odds ratio, 12.0; 95% confidence interval, 1.9-74). Among the patients with ARDS, the 54BB genotype was associated with more daily organ dysfunction (p = .01) and higher mortality (adjusted hazard rate, 4.0; 95% confidence interval, 1.6-10). Development of ARDS and outcomes in ARDS did not vary significantly with variant alleles of codon -221, 52, and 57, but the power to detect an effect was limited secondary to the low allele frequencies.

Conclusions

The MBL-2 codon 54BB genotype may be important in ARDS susceptibility and outcome. Additional studies are needed to confirm these findings in other populations.

SUBMITTER: Gong MN

PROVIDER: S-EPMC3090269 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Polymorphisms in the mannose binding lectin-2 gene and acute respiratory distress syndrome.

Gong Michelle N MN Zhou Wei W Williams Paige L PL Thompson B Taylor BT Pothier Lucille L Christiani David C DC

Critical care medicine 20070101 1

<h4>Objective</h4>The variant alleles in the mannose binding lectin-2 (MBL-2) gene have been associated with MBL deficiency and increased susceptibility to sepsis. We postulate that the variant MBL-2 genotypes are associated with increased susceptibility to and mortality in acute respiratory distress syndrome (ARDS).<h4>Design</h4>Nested case-control study.<h4>Setting</h4>Tertiary academic medical center.<h4>Patients</h4>Two hundred and twelve Caucasians with ARDS and 442 controls genotyped for ...[more]

PMID: 17133182

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Dataset Information

Polymorphisms in the mannose binding lectin-2 gene and acute respiratory distress syndrome.

Objective

Design

Setting

Patients

Interventions

Measurements and main results

Conclusions

Publications

Polymorphisms in the mannose binding lectin-2 gene and acute respiratory distress syndrome.

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