Ontology highlight
ABSTRACT:
SUBMITTER: Obermeier B
PROVIDER: S-EPMC3090654 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Obermeier Birgit B Lovato Laura L Mentele Reinhard R Brück Wolfgang W Forne Ignasi I Imhof Axel A Lottspeich Friedrich F Turk Katherine W KW Willis Simon N SN Wekerle Hartmut H Hohlfeld Reinhard R Hafler David A DA O'Connor Kevin C KC Dornmair Klaus K
Journal of neuroimmunology 20110224 1-2
We investigated the overlap shared between the immunoglobulin (Ig) proteome of the cerebrospinal fluid (CSF) and the B cell Ig-transcriptome of CSF and the central nervous system (CNS) tissue of three patients with multiple sclerosis. We determined the IgG-proteomes of CSF by mass spectrometry, and compared them to the IgG-transcriptomes from CSF and brain lesions, which were analyzed by cDNA cloning. Characteristic peptides that were identified in the CSF-proteome could also be detected in the ...[more]