Ontology highlight
ABSTRACT:
SUBMITTER: Bonacci G
PROVIDER: S-EPMC3091216 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Bonacci Gustavo G Schopfer Francisco J FJ Batthyany Carlos I CI Rudolph Tanja K TK Rudolph Volker V Khoo Nicholas K H NK Kelley Eric E EE Freeman Bruce A BA
The Journal of biological chemistry 20110315 18
Nitro-fatty acids (NO(2)-FA) are electrophilic signaling mediators formed by reactions of nitric oxide and nitrite. NO(2)-FA exert anti-inflammatory signaling actions through post-translational protein modifications. We report that nitro-oleic acid (OA-NO(2)) stimulates proMMP-7 and proMMP-9 proteolytic activity via adduction of the conserved cysteine switch domain thiolate. Biotin-labeled OA-NO(2) showed this adduction occurs preferentially with latent forms of MMP, confirming a role for thiol ...[more]