Ontology highlight
ABSTRACT:
SUBMITTER: Orgaz JL
PROVIDER: S-EPMC4118761 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Orgaz Jose L JL Pandya Pahini P Dalmeida Rimple R Karagiannis Panagiotis P Sanchez-Laorden Berta B Viros Amaya A Albrengues Jean J Nestle Frank O FO Ridley Anne J AJ Gaggioli Cedric C Marais Richard R Karagiannis Sophia N SN Sanz-Moreno Victoria V
Nature communications 20140625
Rounded-amoeboid cancer cells use actomyosin contractility driven by Rho-ROCK and JAK-STAT3 to migrate efficiently. It has been suggested that rounded-amoeboid cancer cells do not require matrix metalloproteinases (MMPs) to invade. Here we compare MMP levels in rounded-amoeboid and elongated-mesenchymal melanoma cells. Surprisingly, we find that rounded-amoeboid melanoma cells secrete higher levels of several MMPs, including collagenase MMP-13 and gelatinase MMP-9. As a result, rounded-amoeboid ...[more]