Ontology highlight
ABSTRACT:
SUBMITTER: Naik PK
PROVIDER: S-EPMC3091960 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Naik Pradeep K PK Santoshi Seneha S Rai Ankit A Joshi Harish C HC
Journal of molecular graphics & modelling 20110409 7
We have previously discovered the tubulin-binding anti-cancer properties of noscapine and its derivatives (noscapinoids). Here, we present three lines of evidence that noscapinoids bind at or near the well studied colchicine binding site of tubulin: (1) in silico molecular docking studies of Br-noscapine and noscapine yield highest docking score with the well characterised colchicine-binding site from the co-crystal structure; (2) the molecular mechanics-generalized Born/surface area (MM-GB/SA) ...[more]