Ontology highlight
ABSTRACT:
SUBMITTER: Vicente-Blazquez A
PROVIDER: S-EPMC8439230 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Vicente-Blázquez Alba A González Myriam M Medarde Manuel M Mollinedo Faustino F Peláez Rafael R
Journal of enzyme inhibition and medicinal chemistry 20211201 1
Searching for improved indolesulfonamides with higher polarities, 45 new analogues with modifications on the sulfonamide nitrogen, the methoxyaniline, and/or the indole 3-position were synthesised. They show submicromolar to nanomolar antiproliferative IC<sub>50</sub> values against four human tumour cell lines and they are not P-glycoprotein substrates as their potencies against HeLa cells did not improve upon cotreatment with multidrug resistance (MDR) inhibitors. The compounds inhibit tubulin ...[more]