Ontology highlight
ABSTRACT:
SUBMITTER: Bera S
PROVIDER: S-EPMC3092388 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Bera Smritilekha S Linhardt Robert J RJ
The Journal of organic chemistry 20110407 9
Triazole linked heparosan and chondroitin disaccharide and tetrasaccharide building blocks were synthesized in a stereoselective manner by applying a very efficient copper catalyzed azide-alkyne cycloaddition (CuAAC) reaction of appropriately substituted azido-glucuronic acid and propargyluted N-acetyl glucosamine and N-acetyl galactosamine derivative, respectively. The resulting suitably substituted tetrasaccharide analogues can be easily converted into azide and alkyne unit for further synthes ...[more]