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Synthesis and minisci reactions of organotrifluoroborato building blocks.

ABSTRACT: Copper-catalyzed borylation of a variety of organic halides with bis(pinacolato)diboron allows the preparation of diverse potassium organotrifluoroborates. The reactions are mild and general, providing access to a variety of interesting, boron-containing building blocks, including those containing piperidine, pyrrole, azetidine, tetrahydropyran, and oxetane substructures. Representative Minisci reactions are reported for select examples.

SUBMITTER: Presset M

PROVIDER: S-EPMC3678362 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Synthesis and minisci reactions of organotrifluoroborato building blocks.

Presset Marc M Fleury-Brégeot Nicolas N Oehlrich Daniel D Rombouts Frederik F Molander Gary A GA

The Journal of organic chemistry 20130417 9

Copper-catalyzed borylation of a variety of organic halides with bis(pinacolato)diboron allows the preparation of diverse potassium organotrifluoroborates. The reactions are mild and general, providing access to a variety of interesting, boron-containing building blocks, including those containing piperidine, pyrrole, azetidine, tetrahydropyran, and oxetane substructures. Representative Minisci reactions are reported for select examples. ...[more]

PMID: 23594305

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