Ontology highlight
ABSTRACT:
SUBMITTER: Ho YP
PROVIDER: S-EPMC3092798 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Ho Yi-Ping YP Grigsby Christopher L CL Zhao Feng F Leong Kam W KW
Nano letters 20110420 5
The future of genetic medicine hinges on successful intracellular delivery of nucleic acid-based therapeutics. While significant effort has concentrated on developing nanocarriers to improve the delivery aspects, scant attention has been paid to the synthetic process of poorly controlled nanocomplex formation. Proposed here is a reliable system to better control the complexation process, and thus the physical properties of the nanocomplexes, through microfluidics-assisted confinement (MAC) in pi ...[more]