Ontology highlight
ABSTRACT:
SUBMITTER: Gardaneh M
PROVIDER: S-EPMC3093024 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Gardaneh Mossa M Gholami Mostafa M Maghsoudi Nader N
Rejuvenation research 20110111 2
The degeneration of dopaminergic neurons in the course of Parkinson disease is largely blamed on oxidative damage in the brain. This study examined the potency of glutathione peroxidase-1 (GPX-1) to protect dopaminergic neurons against toxicity induced by the parkinsonian neurotoxin 6-hydroxydopamine (6-OHDA). We generated pLV-GPX1, a recombinant lentivirus vector carrying the coding sequence for human GPX-1, into the SK-N-MC neuroblastoma cell line. The pLV-GPX1-infected neurons showed an over ...[more]