Ontology highlight
ABSTRACT:
SUBMITTER: Henrich SM
PROVIDER: S-EPMC5269693 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Henrich Sarah Marie SM Usadel Clemens C Werwein Eugen E Burdova Kamila K Janscak Pavel P Ferrari Stefano S Hess Daniel D Klempnauer Karl-Heinz KH
Scientific reports 20170127
B-Myb, a highly conserved member of the Myb transcription factor family, is expressed ubiquitously in proliferating cells and controls the cell cycle dependent transcription of G2/M-phase genes. Deregulation of B-Myb has been implicated in oncogenesis and loss of genomic stability. We have identified B-Myb as a novel interaction partner of the Mre11-Rad50-Nbs1 (MRN) complex, a key player in the repair of DNA double strand breaks. We show that B-Myb directly interacts with the Nbs1 subunit of the ...[more]