Hypervalent organochalcogenanes as inhibitors of protein tyrosine phosphatases.

ABSTRACT: A series of organochalcogenanes was synthesized and evaluated as protein tyrosine phosphatases (PTPs) inhibitors. The results indicate that organochalcogenanes inactivate the PTPs in a time- and concentration-dependent fashion, most likely through covalent modification of the active site sulfur-moiety by the chalcogen atom. Consequently, organochalcogenanes represent a new class of mechanism-based probes to modulate the PTP-mediated cellular processes.

SUBMITTER: Piovan L 

PROVIDER: S-EPMC3093659 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature