Virological and cellular roles of the transcriptional coactivator LEDGF/p75.
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ABSTRACT:
SUBMITTER: Llano M
PROVIDER: S-EPMC3093762 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Publications
Virological and cellular roles of the transcriptional coactivator LEDGF/p75.
Llano Manuel M Morrison James J Poeschla Eric M EM
Current topics in microbiology and immunology 20090101
The chromatin-associated cellular proteins LEDGF/p75 and LEDGF/p52 have been implicated in transcriptional regulation, cell survival and autoimmunity. LEDGF/p75 also appears to act as a chromatin-docking factor or receptor for HIV-1 and other lentiviruses and to play a role in leukemogenesis. For both the viral and cellular roles of this protein, a key feature is its ability to act as a molecular adaptor and tether proteins to the chromatin fiber. This chapter reviews the emerging roles of LEDGF ...[more]
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