Ontology highlight
ABSTRACT:
SUBMITTER: Palani S
PROVIDER: S-EPMC3094063 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Molecular systems biology 20110301
The ability to engineer an all-or-none cellular response to a given signaling ligand is important in applications ranging from biosensing to tissue engineering. However, synthetic gene network 'switches' have been limited in their applicability and tunability due to their reliance on specific components to function. Here, we present a strategy for reversible switch design that instead relies only on a robust, easily constructed network topology with two positive feedback loops and we apply the m ...[more]