Ontology highlight
ABSTRACT:
SUBMITTER: Strappazzon F
PROVIDER: S-EPMC3094111 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Strappazzon Flavie F Vietri-Rudan Matteo M Campello Silvia S Nazio Francesca F Florenzano Fulvio F Fimia Gian Maria GM Piacentini Mauro M Levine Beth B Cecconi Francesco F
The EMBO journal 20110225 7
BECLIN 1 is a central player in macroautophagy. AMBRA1, a BECLIN 1-interacting protein, positively regulates the BECLIN 1-dependent programme of autophagy. In this study, we show that AMBRA1 binds preferentially the mitochondrial pool of the antiapoptotic factor BCL-2, and that this interaction is disrupted following autophagy induction. Further, AMBRA1 can compete with both mitochondrial and endoplasmic reticulum-resident BCL-2 (mito-BCL-2 and ER-BCL-2, respectively) to bind BECLIN 1. Moreover, ...[more]