Ontology highlight
ABSTRACT:
SUBMITTER: Perez C
PROVIDER: S-EPMC3094121 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Perez Camilo C Koshy Caroline C Ressl Susanne S Nicklisch Sascha S Krämer Reinhard R Ziegler Christine C
The EMBO journal 20110301 7
BetP is an Na(+)-coupled betaine-specific transporter of the betaine-choline-carnitine (BCC) transporter family involved in the response to hyperosmotic stress. The crystal structure of BetP revealed an overall fold of two inverted structurally related repeats (LeuT-fold) that BetP shares with other sequence-unrelated Na(+)-coupled symporters. Numerous structures of LeuT-fold transporters in distinct conformational states have contributed substantially to our understanding of the alternating acc ...[more]