Ontology highlight
ABSTRACT:
SUBMITTER: Minor RK
PROVIDER: S-EPMC3094497 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Minor Robin K RK López Miguel M Younts Caitlin M CM Jones Bruce B Pearson Kevin J KJ Anson Robert Michael RM Diéguez Carlos C de Cabo Rafael R de Cabo Rafael R
Aging cell 20110405 3
Calorie restriction (CR) is known to have profound effects on tumor incidence. A typical consequence of CR is hunger, and we hypothesized that the neuroendocrine response to CR might in part mediate CR's antitumor effects. We tested CR under appetite suppression using two models: neuropeptide Y (NPY) knockout mice and monosodium glutamate-injected mice. While CR was protective in control mice challenged with a two-stage skin carcinogenesis model, papilloma development was neither delayed nor red ...[more]