Ontology highlight
ABSTRACT:
SUBMITTER: Kim MS
PROVIDER: S-EPMC3094717 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Biochemical and biophysical research communications 20080317 1
The pathogenesis of breast cancer involves multiple genetic and epigenetic events. In this study, we report an epigenetic alteration of DFNA5 in human breast cancer. DFNA5 gene was silenced in breast cancer cell lines that were methylated in the DFNA5 promoter, and restored by treatment with the demethylating agent, 5-aza-dC, and gene knock-down of DFNA5 increased cellular invasiveness in vitro. The mRNA expression of DFNA5 in breast cancer tissues was down-regulated as compared to normal tissue ...[more]