Ontology highlight
ABSTRACT:
SUBMITTER: Xiao B
PROVIDER: S-EPMC3097298 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Xiao Bailong B Coste Bertrand B Mathur Jayanti J Patapoutian Ardem A
Nature chemical biology 20110417 6
Intracellular Ca(2+) is essential for diverse cellular functions. Ca(2+) entry into many cell types including immune cells is triggered by depleting endoplasmic reticulum (ER) Ca(2+), a process termed store-operated Ca(2+) entry (SOCE). STIM1 is an ER Ca(2+) sensor. Upon Ca(2+) store depletion, STIM1 clusters at ER-plasma membrane junctions where it interacts with and gates Ca(2+)-permeable Orai1 ion channels. Here we show that STIM1 is also activated by temperature. Heating cells caused cluster ...[more]