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Regulator of G-protein signaling 14 protein modulates Ca²+ influx through Cav1 channels.


ABSTRACT: Calcium flux through L-type voltage-activated calcium (Cav1) channels is crucial for regulating brain functions including memory formation and behavior. Alterations in Ca²+ homeostasis have been linked to many cognitive disorders, and understanding the regulation of this process is crucial for their remedy. Therefore, here, we have evaluated the effect of a multifunctional protein known to be involved in memory functions called regulator of G-protein signaling 14 (RGS-14) on Cav1 channel activity in neuronal cell lines NG108-15 and SH-SY5Y. RGS-14 protein produced significant reduction in Ca²+ influx in both cell lines and this effect was dependent on nifedipine-sensitive Cav1 channels. Thus, our results provide evidence supporting the idea that RGS-14 may facilitate the cognitive processing by modulating Cav1 channel-mediated intracellular Ca²+ transients.

SUBMITTER: Martin-Montanez E 

PROVIDER: S-EPMC3181207 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature

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Regulator of G-protein signaling 14 protein modulates Ca²+ influx through Cav1 channels.

Martín-Montañez Elisa E   Acevedo Maria José MJ   López-Téllez Juan Félix JF   Duncan Raymond Scott RS   Mateos Antonio González AG   Pavía José J   Koulen Peter P   Khan Zafar U ZU  

Neuroreport 20101101 16


Calcium flux through L-type voltage-activated calcium (Cav1) channels is crucial for regulating brain functions including memory formation and behavior. Alterations in Ca²+ homeostasis have been linked to many cognitive disorders, and understanding the regulation of this process is crucial for their remedy. Therefore, here, we have evaluated the effect of a multifunctional protein known to be involved in memory functions called regulator of G-protein signaling 14 (RGS-14) on Cav1 channel activit  ...[more]

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