Ontology highlight
ABSTRACT:
SUBMITTER: Craig AL
PROVIDER: S-EPMC3098010 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Craig Ashley L AL Holcakova Jitka J Finlan Lee E LE Nekulova Marta M Hrstka Roman R Gueven Nuri N DiRenzo James J Smith Graeme G Hupp Ted R TR Vojtesek Borivoj B
Molecular cancer 20100721
<h4>Background</h4>DeltaNp63alpha is an epithelial progenitor cell marker that maintains epidermal stem cell self-renewal capacity. Previous studies revealed that UV-damage induced p53 phosphorylation is confined to DeltaNp63alpha-positive cells in the basal layer of human epithelium.<h4>Results</h4>We now report that phosphorylation of the p53 tumour suppressor is positively regulated by DeltaNp63alpha in immortalised human keratinocytes. DeltaNp63alpha depletion by RNAi reduces steady-state AT ...[more]