Ontology highlight
ABSTRACT:
SUBMITTER: Gao XC
PROVIDER: S-EPMC3098244 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Gao Xue-Chao XC Zhou Chen-Jie CJ Zhou Zi-Ren ZR Zhang Yu-Hang YH Zheng Xue-Ming XM Song Ai-Xin AX Hu Hong-Yu HY
PloS one 20110519 5
Homo sapiens J domain protein (HSJ1) is a J-domain containing co-chaperone that is known to stimulate ATPase activity of HSP70 chaperone, while it also harbors two ubiquitin (Ub)-interacting motifs (UIMs) that may bind with ubiquitinated substrates and potentially function in protein degradation. We studied the effects of HSJ1a on the protein levels of both normal and the disease--related polyQ-expanded forms of ataxin-3 (Atx3) in cells. The results demonstrate that the N-terminal J-domain and t ...[more]