Ontology highlight
ABSTRACT:
SUBMITTER: Haller M
PROVIDER: S-EPMC4502749 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Haller Martina M Hock Andreas K AK Giampazolias Evangelos E Oberst Andrew A Green Douglas R DR Debnath Jayanta J Ryan Kevin M KM Vousden Karen H KH Tait Stephen W G SW
Autophagy 20140101 12
During macroautophagy, conjugation of ATG12 to ATG5 is essential for LC3 lipidation and autophagosome formation. Additionally, ATG12 has ATG5-independent functions in diverse processes including mitochondrial fusion and mitochondrial-dependent apoptosis. In this study, we investigated the regulation of free ATG12. In stark contrast to the stable ATG12-ATG5 conjugate, we find that free ATG12 is highly unstable and rapidly degraded in a proteasome-dependent manner. Surprisingly, ATG12, itself a ub ...[more]