Ontology highlight
ABSTRACT:
SUBMITTER: Bhogaraju S
PROVIDER: S-EPMC3098482 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
The EMBO journal 20110419 10
The cilium is an important organelle that is found on many eukaryotic cells, where it serves essential functions in motility, sensory reception and signalling. Intraflagellar transport (IFT) is a vital process for the formation and maintenance of cilia. We have determined the crystal structure of Chlamydomonas reinhardtii IFT25/27, an IFT sub-complex, at 2.6 Å resolution. IFT25 and IFT27 interact via a conserved interface that we verify biochemically using structure-guided mutagenesis. IFT27 dis ...[more]