Ontology highlight
ABSTRACT:
SUBMITTER: Webb S
PROVIDER: S-EPMC7561706 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Webb Stephanie S Mukhopadhyay Aakash G AG Roberts Anthony J AJ
Seminars in cell & developmental biology 20200716
Intraflagellar transport (IFT) sculpts the proteome of cilia and flagella; the antenna-like organelles found on the surface of virtually all human cell types. By delivering proteins to the growing ciliary tip, recycling turnover products, and selectively transporting signalling molecules, IFT has critical roles in cilia biogenesis, quality control, and signal transduction. IFT involves long polymeric arrays, termed IFT trains, which move to and from the ciliary tip under the power of the microtu ...[more]