Ontology highlight
ABSTRACT:
SUBMITTER: Le UN
PROVIDER: S-EPMC3098638 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Le Uyenchi N UN Kim Hyung-Seok HS Kwon Jin-Sook JS Kim Mi Yeon MY Nguyen Vu H VH Jiang Sheng Nan SN Lee Byeong-Il BI Hong Yeongjin Y Shin Myung Geun MG Rhee Joon Haeng JH Bom Hee-Seung HS Ahn Youngkeun Y Gambhir Sanjiv S SS Choy Hyon E HE Min Jung-Joon JJ
Molecular therapy : the journal of the American Society of Gene Therapy 20110301 5
Optimization of the specific affinity of cardiac delivery vector could significantly improve the efficiency of gene/protein delivery, yet no cardiac vectors to date have sufficient target specificity for myocardial infarction (MI). In this study, we explored bacterial tropism for infarcted myocardium based on our previous observations that certain bacteria are capable of targeting the hypoxic regions in solid tumors. Out of several Escherichia coli or Salmonella typhimurium strains, the S. typhi ...[more]