An in Vivo miRNA Delivery System for Restoring Infarcted Myocardium.
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ABSTRACT:
SUBMITTER: Yang H
PROVIDER: S-EPMC7930012 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
An <i>in Vivo</i> miRNA Delivery System for Restoring Infarcted Myocardium.
Yang Huaxiao H Qin Xulei X Wang Huiyuan H Zhao Xin X Liu Yonggang Y Wo Hung-Ta HT Liu Chun C Nishiga Masataka M Chen Haodong H Ge Jing J Sayed Nazish N Abilez Oscar J OJ Ding Dan D Heilshorn Sarah C SC Li Kai K
ACS nano 20190607 9
A major challenge in myocardial infarction (MI)-related heart failure treatment using microRNA is the efficient and sustainable delivery of miRNAs into myocardium to achieve functional improvement through stimulation of intrinsic myocardial restoration. In this study, we established an <i>in vivo</i> delivery system using polymeric nanoparticles to carry miRNA (miNPs) for localized delivery within a shear-thinning injectable hydrogel. The miNPs triggered proliferation of human embryonic stem cel ...[more]
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