Ontology highlight
ABSTRACT:
SUBMITTER: Jones PW
PROVIDER: S-EPMC3098801 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Jones Paul W PW Rennard Stephen I SI Agusti Alvar A Chanez Pascal P Magnussen Helgo H Fabbri Leonardo L Donohue James F JF Bateman Eric D ED Gross Nicholas J NJ Lamarca Rosa R Caracta Cynthia C Gil Esther Garcia EG
Respiratory research 20110426
<h4>Background</h4>The long-term efficacy and safety of aclidinium bromide, a novel, long-acting muscarinic antagonist, were investigated in patients with moderate to severe chronic obstructive pulmonary disease (COPD).<h4>Methods</h4>In two double-blind, 52-week studies, ACCLAIM/COPD I (n=843) and II (n=804), patients were randomised to inhaled aclidinium 200 μg or placebo once-daily. Patients were required to have a post-bronchodilator forced expiratory volume in 1 second (FEV1)/forced vital c ...[more]