Ontology highlight
ABSTRACT:
SUBMITTER: Schirner K
PROVIDER: S-EPMC3098905 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Schirner Kathrin K Stone Laura K LK Walker Suzanne S
ACS chemical biology 20110215 5
The cell envelopes of Gram-positive bacteria comprise two major constituents, peptidoglycan and teichoic acids. Wall teichoic acids (WTAs) are anionic glycophosphate polymers that play important roles in bacterial cell growth, division, and pathogenesis. They are synthesized intracellularly and exported by an ABC transporter to the cell surface, where they are covalently attached to peptidoglycan. We address here the substrate specificity of WTA transporters by substituting the Bacillus subtilis ...[more]