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Current progress in pharmacogenetics.

ABSTRACT: The study of genetic variation has the potential to aid understanding of the mechanisms underlying the observed inter-individual variation in drug response and by which idiosyncratic adverse effects occur. In this review, we outline current progress in pharmacogenetics using examples to highlight both mechanisms of influence of polymorphisms and research strategies for their detection. In the final sections we discuss contemporary challenges for both researchers and clinicians.

SUBMITTER: Blakey JD

PROVIDER: S-EPMC3099369 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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Current progress in pharmacogenetics.

Blakey John D JD Hall Ian P IP

British journal of clinical pharmacology 20110601 6

The study of genetic variation has the potential to aid understanding of the mechanisms underlying the observed inter-individual variation in drug response and by which idiosyncratic adverse effects occur. In this review, we outline current progress in pharmacogenetics using examples to highlight both mechanisms of influence of polymorphisms and research strategies for their detection. In the final sections we discuss contemporary challenges for both researchers and clinicians. ...[more]

PMID: 21235621

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