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Synthesis and properties of triazole-linked RNA.

ABSTRACT: RNA oligonucleotides having triazole linkages between uridine and adenosine nucleosides have been prepared and studied using spectroscopic techniques. UV melting and CD showed that triazole strongly destabilized RNA duplex (7-14°C per modification). NMR data suggested that, despite relative flexibility around the modified linkage, all base pairs were formed.

SUBMITTER: Mutisya D

PROVIDER: S-EPMC3099469 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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Synthesis and properties of triazole-linked RNA.

Mutisya Daniel D Selvam Chelliah C Kennedy Scott D SD Rozners Eriks E

Bioorganic & medicinal chemistry letters 20110405 11

RNA oligonucleotides having triazole linkages between uridine and adenosine nucleosides have been prepared and studied using spectroscopic techniques. UV melting and CD showed that triazole strongly destabilized RNA duplex (7-14°C per modification). NMR data suggested that, despite relative flexibility around the modified linkage, all base pairs were formed. ...[more]

PMID: 21524577

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