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Synthesis of triazole-linked morpholino oligonucleotides via Cu(I) catalysed cycloaddition.

ABSTRACT: Triazole-linked morpholino ((TL)MO) oligonucleic acids were synthesised using the Cu(I) catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the (TL)MO modification gives higher Tm values than the corresponding (TL)DNA modification.

SUBMITTER: Palframan MJ 

PROVIDER: S-EPMC5047124 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Synthesis of triazole-linked morpholino oligonucleotides via Cu(I) catalysed cycloaddition.

Palframan Matthew J MJ   Alharthy Rima D RD   Powalowska Paulina K PK   Hayes Christopher J CJ  

Organic & biomolecular chemistry 20160224 11

Triazole-linked morpholino ((TL)MO) oligonucleic acids were synthesised using the Cu(I) catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the (TL)MO modification gives higher Tm values than the corresponding (TL)DNA modification. ...[more]

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