Ontology highlight
ABSTRACT:
SUBMITTER: Palframan MJ
PROVIDER: S-EPMC5047124 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Organic & biomolecular chemistry 20160224 11
Triazole-linked morpholino ((TL)MO) oligonucleic acids were synthesised using the Cu(I) catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the (TL)MO modification gives higher Tm values than the corresponding (TL)DNA modification. ...[more]