Ontology highlight
ABSTRACT:
SUBMITTER: Bindman NA
PROVIDER: S-EPMC4505723 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Bindman Noah A NA Bobeica Silvia C SC Liu Wenshe R WR van der Donk Wilfred A WA
Journal of the American Chemical Society 20150601 22
The biosynthesis of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products typically involves a precursor peptide which contains a leader peptide that is important for the modification process, and that is removed in the final step by a protease. Genome mining efforts for new RiPPs are often hampered by the lack of a general method to remove the leader peptides. We describe here the incorporation of hydroxy acids into the precursor peptides in E. coli which res ...[more]