Ontology highlight
ABSTRACT:
SUBMITTER: Giulino L
PROVIDER: S-EPMC3100694 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Blood 20110315 18
A20, a negative regulator of NF-κB, has been implicated as a tumor suppressor gene in multiple types of B-cell lymphoma. AIDS-related lymphomas (ARLs) are high-grade B-cell lymphomas that are frequently associated with EBV infection. We examined a panel of ARLs for A20 alterations. FISH showed A20 deletion in 6 of 33 cases (18%). A20 mutations were found in 3 of 19 cases (16%), including 2 cases with deletions of the comple-mentary allele. Immunohistochemistry showed the absence of A20 protein i ...[more]