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Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia

ABSTRACT: We identified a novel recurrent genetic lesion in T-LGL. Mutations of the tumour suppressor gene TNFAIP3 causing amino-acid exchanges or protein truncations were seen in 3/39 cases (8%).

ORGANISM(S): Homo sapiens

PROVIDER: GSE69735 | GEO | 2016/06/12

SECONDARY ACCESSION(S): PRJNA286292

REPOSITORIES: GEO

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Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia

Project description:We identified a novel recurrent genetic lesion in T-LGL. Mutations of the tumour suppressor gene TNFAIP3 causing amino-acid exchanges or protein truncations were seen in 3/39 cases (8%). RNA sequencing (Illumina HiSeq 2500) of 5 index patients with paired tumor and non-tumor samples.

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