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Antimicrobial peptoids are effective against Pseudomonas aeruginosa biofilms.

ABSTRACT: The resistance of biofilms to conventional antibiotics complicates the treatment of chronic cystic fibrosis (CF). We investigated the effects of peptoids, peptides, and conventional antibiotics on the biomass and cell viability within Pseudomonas aeruginosa biofilms. At their MICs, peptoids 1 and 1-C13(4mer) caused maximum reductions in biomass and cell viability, respectively. These results suggest that peptoids of this class could be worth exploring for the treatment of pulmonary infections occurring in CF patients.

SUBMITTER: Kapoor R

PROVIDER: S-EPMC3101385 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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Antimicrobial peptoids are effective against Pseudomonas aeruginosa biofilms.

Kapoor Rinki R Wadman Mayken W MW Dohm Michelle T MT Czyzewski Ann M AM Spormann Alfred M AM Barron Annelise E AE

Antimicrobial agents and chemotherapy 20110321 6

The resistance of biofilms to conventional antibiotics complicates the treatment of chronic cystic fibrosis (CF). We investigated the effects of peptoids, peptides, and conventional antibiotics on the biomass and cell viability within Pseudomonas aeruginosa biofilms. At their MICs, peptoids 1 and 1-C13(4mer) caused maximum reductions in biomass and cell viability, respectively. These results suggest that peptoids of this class could be worth exploring for the treatment of pulmonary infections oc ...[more]

PMID: 21422218

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