Ontology highlight
ABSTRACT:
SUBMITTER: Di Bonaventura I
PROVIDER: S-EPMC5643981 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Di Bonaventura Ivan I Jin Xian X Visini Ricardo R Probst Daniel D Javor Sacha S Gan Bee-Ha BH Michaud Gaëlle G Natalello Antonino A Doglia Silvia Maria SM Köhler Thilo T van Delden Christian C Stocker Achim A Darbre Tamis T Reymond Jean-Louis JL
Chemical science 20170713 10
Herein we report the discovery of antimicrobial bridged bicyclic peptides (AMBPs) active against <i>Pseudomonas aeruginosa</i>, a highly problematic Gram negative bacterium in the hospital environment. Two of these AMBPs show strong biofilm inhibition and dispersal activity and enhance the activity of polymyxin, currently a last resort antibiotic against which resistance is emerging. To discover our AMBPs we used the concept of chemical space, which is well known in the area of small molecule dr ...[more]