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A novel gene cassette, aacA43, in a plasmid-borne class 1 integron.


ABSTRACT: A novel gene cassette, aacA43, was identified in the aadB-aacA43-oxa10-smr2 cassette array in a class 1 integron. Like related aminoglycoside-(6')-acetyltransferases, AacA43 confers clinically relevant resistance to kanamycin, tobramycin, and some less-used aminoglycosides but not to gentamicin. Although transferable on an IncL/M plasmid, aacA43 was identified in only two different Klebsiella pneumoniae strains (14 isolates), one Escherichia coli strain (2 isolates), and one Enterobacter cloacae strain in a survey of patients in a Sydney intensive care unit in 2004-2005.

SUBMITTER: Partridge SR 

PROVIDER: S-EPMC3101451 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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A novel gene cassette, aacA43, in a plasmid-borne class 1 integron.

Partridge Sally R SR   Thomas Lee C LC   Ginn Andrew N AN   Wiklendt Agnieszka M AM   Kyme Pierre P   Iredell Jonathan R JR  

Antimicrobial agents and chemotherapy 20110321 6


A novel gene cassette, aacA43, was identified in the aadB-aacA43-oxa10-smr2 cassette array in a class 1 integron. Like related aminoglycoside-(6')-acetyltransferases, AacA43 confers clinically relevant resistance to kanamycin, tobramycin, and some less-used aminoglycosides but not to gentamicin. Although transferable on an IncL/M plasmid, aacA43 was identified in only two different Klebsiella pneumoniae strains (14 isolates), one Escherichia coli strain (2 isolates), and one Enterobacter cloacae  ...[more]

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