Pregnane X receptor- and CYP3A4-humanized mouse models and their applications.
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ABSTRACT:
SUBMITTER: Cheng J
PROVIDER: S-EPMC3101609 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Publications
Pregnane X receptor- and CYP3A4-humanized mouse models and their applications.
Cheng Jie J Ma Xiaochao X Gonzalez Frank J FJ
British journal of pharmacology 20110601 3
Pregnane X receptor (PXR) is a pivotal nuclear receptor modulating xenobiotic metabolism primarily through its regulation of CYP3A4, the most important enzyme involved in drug metabolism in humans. Due to the marked species differences in ligand recognition by PXR, PXR-humanized (hPXR) mice, and mice expressing human PXR and CYP3A4 (Tg3A4/hPXR) were established. hPXR and Tg3A4/hPXR mice are valuable models for investigating the role of PXR in xenobiotic metabolism and toxicity, in lipid, bile ac ...[more]
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