Ontology highlight
ABSTRACT:
SUBMITTER: Lim YP
PROVIDER: S-EPMC3356939 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Lim Yun-Ping YP Ma Chia-Yun CY Liu Cheng-Ling CL Lin Yu-Hsien YH Hu Miao-Lin ML Chen Jih-Jung JJ Hung Dong-Zong DZ Hsieh Wen-Tsong WT Huang Jin-Ding JD
Evidence-based complementary and alternative medicine : eCAM 20120507
Inconsistent expression and regulation of drug-metabolizing enzymes (DMEs) are common causes of adverse drug effects in some drugs with a narrow therapeutic index (TI). An important cytochrome, cytochrome P450 3A4 (CYP3A4), is predominantly regulated by a nuclear receptor, pregnane X receptor (PXR). Sesamin, a major lignan constituent in sesame seeds and oil, exhibits a variety of biological functions; however, the effect of sesamin on the modulation of CYP3A4 is not well understood. In this stu ...[more]